| Jogo | Data | Hora | EqCasa | GlC | GlF | EqFora |
|---|---|---|---|---|---|---|
| 4 | 2021-10-01 | 19:00 | Marítimo | 0 | 0 | Moreirense |
| 8 | 2021-10-01 | 21:15 | FC Famalicão | 1 | 2 | V. Guimarães |
| 2 | 2021-10-02 | 15:30 | FC Vizela | 1 | 1 | Santa Clara |
| 9 | 2021-10-02 | 18:00 | FC Porto | 2 | 1 | P. Ferreira |
| 3 | 2021-10-02 | 20:30 | Arouca | 1 | 2 | Sporting |
| 5 | 2021-10-03 | 15:30 | Belenenses SAD | 0 | 2 | Tondela |
| 6 | 2021-10-03 | 16:00 | Benfica | 0 | 1 | Portimonense |
| 1 | 2021-10-03 | 18:00 | Estoril Praia | 2 | 2 | Gil Vicente |
| 7 | 2021-10-03 | 20:30 | SC Braga | 2 | 2 | Boavista |